The Discovery of Bacterium Causing Stomach Ulcers

For decades the medical community believed gastric ulcers were directly related to stress with the only options for relief being antacids and surgery. In the early 1980’s, Australian physicians Barry Marshall and Robin Warren discovered through biopsies of gastric ulcers, that nearly all were overrun by helicobacter pylori bacteria. Helicobacter pylori only seems to infect humans, as studies performed upon pigs and rats were unsuccessful as these animals were unable to contract the bacterium. Marshall decided to infect himself and within 5 days of doing so, he started running to the bathroom each morning to throw up. Tests demonstrated that Marshall had gastritis, a precursor to an ulcer. Marshall took antibiotics and was cured, proving once and for all that ulcers are caused by bacteria not stress. In 2005, Marshall and Warren won the Nobel Prize in Medicine for their findings

The Reason Most Cats Adore Cat Nip

Catnip is a perennial herb which is a member of the mint family, specifically the species of the genus Nepeta (pronounced “nah-pee-tah”) in the family Lamiaceae (pronounced “lah-me-yay-see-aye”). The chemical compound in the nepeta cataria plant which attracts and affects felines is nepetalactone (pronounced “nah-pee-tal-ack-tone”). Nepetalactone is indigenous to Southern and Eastern Europe, the Middle East, Central Asia, and parts of China. When cats consume catnip orally the compound acts as a sedative, but when inhaled for its scent, it causes short bursts of hyperactivity. Nepetalactone is extracted via steam distillation and acts as a natural mosquito and fly repellent. Several scientific studies have demonstrated that leopards, cougars, and various species of lynx often react to catnip in a similar manner to their domestic house cat cousins, whilst lions and tigers may react strongly, but may also have little or no reaction whatsoever. 33% of cats are unaffected by catnip with the behavior theorized to be hereditary in nature. In 1962, it was discovered that susceptibility to catnip may be directly related to the Mendelian-dominant gene. Other plants can have similar effects upon felines including the roots and leafs of the valerian plant, silver vine which is sometimes referred to as “matatabi”, and Tatarian honeysuckle wood. Cats who do not respond to nepeta cataria are more likely to respond to one, some, or all of these alternatives plants. In addition to its use with cats, nepeta cataria is also a popular ingredient in herbal tisanes and teas, and is highly valued for its sedative and relaxant properties”

The First U.S. Presidential Vaccine Mandate

U.S. President George Washington issued the first presidential vaccine mandate, requiring all soldiers within the continental army to become vaccinated against smallpox on February 5, 1777. 90% of deaths during the American Revolution were due to disease, with smallpox being the most prevalent and difficult pathogen for the military to control. Immunization was viewed as an achievable solution to a virtually insurmountable problem as death from smallpox plunged from 30% to 2% after a becomming immunized. Vaccination, or “variolation” as it was referred to during the era, was achieved by taking a small piece of an active smallpox sore from an infected person, and then introducing it to the person being inoculated via inhalation or by scratching their arm and introducing the virus by touch. The mandate, although initially detested, became highly successful in its pursuit of lowering soldier mortality rate, with 40,000 soldiers vaccinated by the end of 1777

The Reason Alcoholic Hangovers are Unpleasant

A hangover at its most basic premise is caused when the body does not have enough water to run its citric acid cycle (also referred to as “CAC”, “tricarboxylic acid cycle”, “TCA cycle”, and/or “Krebs cycle”). This is exactly the process which occurs when a person dies of thirst. Although hangovers are typically not dangerous, this is part of the reason why they feel so uncomfortable

The Study of Bacteriophages in Antibiotic Research and Why They May be the Next Major Scientific Breakthrough

Bacteriophages, which are viral infections that reproduce to target and kill bacteria, were studied in Eastern Europe during the 1950’s by countries which did not have access to western medicine, including antibiotics. In 1 milliliter of sea water, billions of phages are present, with countless different varieties. Phages have tendril like appendages which are used to probe and identify hosts, clinging onto them, then forcing its own deoxyribonucleic acid down into the bacterial host. When this genetic code is introduced, it destroys the bacteria as a direct result. This leads to a chain reaction as hundreds more are produced each time this instance occurs, copies which then fledge out and find hosts of their own, building populations exponentially and wiping out bacterial infections completely. Bacteriophages were found prior to chemical antibiotics but when Penicillin was discovered, because it is so easy to develop and administer, chemical antibiotics became the clear path of choice in medicine with scientists not realizing the severity of this error until decades later. Antibiotics are often broad spectrum which is another reason antibiotic research overshadowed bacteriophagic research as different phages affect different bacteria and are therefore not broad spectrum. Because phages are self-replicating like bacteria, they have the ability to completely annihilate all bacteria presented before them in the same way that bacteria have the ability to totally annihilate their own host as well. Because of this, bacterial infections can be knocked out with 100% efficacy in all cases, regardless of the severity of the the infection, provided the correct phage is alotted enough time to do so. This is a task antibiotics often struggle to achieve and even if achieved, cannot be guaranteed in perpetuity as reinfection or resistance can occur at any time

The Reason Aritifical Intelligence Differs From Traditional Software

Recently, many of the improvements made within the artificial intelligence sector have been due to the technology of “deep learning” which is also referred to as an “artificial neural network”. Traditional software is not intuitive as it simply follows a set of instructions predetermined by a programmer. If the software runs into a new problem which it has no answer prewritten for, it crashes. Deep learning is different as software can now write its own instructions instead of reading the instruction(s) of a programmer. Currently, as of 2021, deep learning is the equivalent of an all powerful, dim witted genie as it has the ability to evaluate the pixels of a photograph of a bottle of water, and can recognize with astonishing accuracy photographs of other water bottles, however it has no idea what the concept of water or the water bottle itself is, what the end user does to drink from the water bottle, what the end user needs the water for etc. This differs in human beings however as humans learn from a sample size of one, and are able to surmise the purpose of water and everything else which is relevant from witnessing it being used upon a single occasion

The Negative Effects Associated With Condom Usage During Sexual Intercourse

Many experts feel as though they cannot talk about the negative aspects of condom usage to promote safe sexual intercourse, however scientifically speaking, there are several negative effects which can be incurred when doing so. The reason these individuals with specific expertise in sexual reproduction, biology, anatomy, and/or physiology do not discuss these issues is because of the fear of spreading misinformation because it’s already difficult to get people to consistently use prophylactics during intercourse, dumping negative information into the public would most likely if not most definitely cause adherence statistics to plummet. With that being said, condom usage can and does on occasion cause 3 different bacterial strains to become present within the vagina, causing erythema both inside the vagina and upon the vulva. The infection is more likely to occur after intercourse has commenced. This rational argument is the most widely used argument within the adult entertainment industry to avoid condoms by performers both male and female. These individuals are tested monthly, sometimes even biweekly for every known kind of sexually transmitted infection and disease, which is why many within the field argue that condoms are an unnecessary risk for them to partake in as their ability to perform sexual acts is their primary source of income and if this is hindered, the consequences could be financially detrimental

The Harvard University Hope Experiment

During the 1950’s, Dr. Curt Richter from Harvard University performed a series of experiments using water, buckets, and both domesticated and wild rats which resulted in a surprising discovery within the field of psychology. In the first experiment, Richter placed his test subjects into large buckets half filled with water with even those rats which were considered above average swimmers, giving up and dying within a few short minutes. In the second experiment, Richter pulled each rat out just as it was about to give up due to exhaustion and let them rest for a few moments. Upon inserting the rats back into the bucket of water, Richter found that the rats continued to struggle to survive for up to 60 hours as the rats now believed that if they continued to push forward with enough effort put forth, eventually they would be rescued once again. Richter recorded in his notes, “after elimination of hopelessness, the rats do not die”

The Test Subject and Scientific Experiment Which Proved the Fear Response in Human Beings Does Not Solely Reside Within the Amygdala

Justin Feinstein is one of the few scientists who have been able to study a woman who has zero fear response. To protect the woman’s identity, this subject is known only as “S.M.”, and Feinstein has had the opportunity to work with her under laboratory conditions and in real world scenarios (e.g. coffee meeting, sporting event, professional conference etc.) for the past 15 years as of 2018. S.M.’s lack of fear has had unexpected consequences within her life, as she displays no sense of typical fear induced scenarios (e.g. personal space, feeling completely comfortable being nose to nose with a complete stranger as the concept of personal space and discomfort has no meaning), heightened by the fact that S.M. does not produce typical signals of distrust when interacting with a novel person. S.M. lacks fear because she is without her amygdala, a physical trait observed in very few human beings, making S.M. one of the only people in the world to produce this physiology. S.M. has no amygdala because she has been diagnosed with Urbach-Wiethe Disease (pronounced “urr-bock vee-they”). The underlying etymology of Urbach-Wiethe Disease is still unknown but in patients with the condition, specific portions of the brain, in both hemispheres, can become subject to selective calcification which erodes the ability to function as designed. The amygdala acts as a sentry for potential fearful stimuli, and produces a response accordingly. The removal of or inability of the amygdala to work correctly results in a complete and total lack and/or loss of fear. This condition has caused S.M. considerable difficulty during her life as she has experienced dangerous interactions with those participating within the illicit drug trade. Upon one occasion, a stranger ran up to S.M., placed a firearm against her temple, and yelled “bang!”. Neighbors witnessed this event and notified law enforcement which puzzled S.M. as she did not view the event as dangerous or alarming and therefore did not expect to be contacted by the police. When the human body detects the intake of too much carbon dioxide, it can become pushed into a state of alarm. Feinstein wanted to better understand what would occur if he interfered with S.M.’s respiratory system, using 35% carbon dioxide during the first trial run. Feinstein found that S.M. was immediately fearful after a single intake breath, despite his original hypothesis of no fear response being observed. S.M. displayed an immediate and dramatic fear response with S.M. herself describing it as the “most intense fear ever felt” during her entire life. This single breath was revolutionary for neurology as it definitively proved that the amygdala is not the only region of the brain which controls and is related to fear

The Rationale Why Pharmaceutical Organizations are Not Incentivized to Develop Antibiotics and Why This is Dangerous for the Worlds Next Pandemic

Within 5 short years of release, approximatly 20% of antibiotics become subject to resistance from bacterial pathogens which means that antibiotic proliferation is chronologically limited within its life expectancy. Coupled with this, if an antibiotic is highly effective, the scientific and medical community often rally against its usage so that such a tool can be saved in reserve for a global bacterial pandemic. In either scenario, return upon investment is less than what it would be with a different class of medication (e.g. selective serotonin re-uptake inhibitor, statin, hypnotic etc.) which is why pharmaceutical organizations are less interested in research and development dedicated to antibiotic medicine in favor of other, more profitable medication categories. This lack of investment however is myopic and will inevitably backfire upon the pharmaceutical industry as a whole if new antibiotics are not developed because medications used to treat cancer will become less in demand due to the fact that cancer patients are highly likely to acquire an infection during treatment when their immune system is comprised, with this infection often killing the patient if antibiotic solutions are not available. This would expectedly lead to a sharp decline in cancer medication treatment and subsequently pharmaceutical sales of related medications as patients would be likely to adopt living the rest of their life as fully as possible and forgoing treatment as they would be damned if they accept the cancer treatment and develop an infection which kills them but also damned if they don’t accept the treatment and let the cancer run its course which is almost always fatal

To provide comparison of the research, development, and manufacturing contrast between oncology medications and antibiotics, as of 2020, there are currently 800 medications in development for cancer and hypertension whilst only 28 antibiotic medications undergoing that same research phase and development process, with 2 of these antibiotics expected to become fully developed and able to reach the market and patients. The last new antibiotic class, lipopeptides, were introduced in 1984 with a gap referred to as an “antibiotic void” occurring during the 1990’s, 2000’s, 2010’s, and now moving into the 2020’s. The urgency of this threat is projected to become dire within the coming decades, with scientists predicting that by 2050, medicine could potentially come full circle to the pre-antibiotic era, with microbes which are completely and totally resistant to every antibiotic known to medicine