The Rationale Why Pharmaceutical Organizations are Not Incentivized to Develop Antibiotics and Why This is Dangerous for the Worlds Next Pandemic

antibiotic-resistanceWithin 5 short years of release, approximatly 20% of antibiotics become subject to resistance from bacterial pathogens which means that antibiotic proliferation is chronologically limited within its life expectancy. Coupled with this, if an antibiotic is highly effective, the scientific and medical community often rally against its usage so that such a tool can be saved in reserve for a global bacterial pandemic. In either scenario, return upon investment is less than what it would be with a different class of medication (e.g. selective serotonin re-uptake inhibitor, statin, hypnotic etc.) which is why pharmaceutical organizations are less interested in research and development dedicated to antibiotic medicine in favor of other, more profitable medication categories. This lack of investment however is myopic and will inevitably backfire upon the pharmaceutical industry as a whole if new antibiotics are not developed because medications used to treat cancer will become less in demand due to the fact that cancer patients are highly likely to acquire an infection during treatment when their immune system is comprised, with this infection often killing the patient if antibiotic solutions are not available. This would expectedly lead to a sharp decline in cancer medication treatment and subsequently pharmaceutical sales of related medications as patients would be likely to adopt living the rest of their life as fully as possible and forgoing treatment as they would be damned if they accept the cancer treatment and develop an infection which kills them but also damned if they don’t accept the treatment and let the cancer run its course which is almost always fatal

To provide comparison of the research, development, and manufacturing contrast between oncology medications and antibiotics, as of 2020, there are currently 800 medications in development for cancer and hypertension whilst only 28 antibiotic medications undergoing that same research phase and development process, with 2 of these antibiotics expected to become fully developed and able to reach the market and patients. The last new antibiotic class, lipopeptides, were introduced in 1984 with a gap referred to as an “antibiotic void” occurring during the 1990’s, 2000’s, 2010’s, and now moving into the 2020’s. The urgency of this threat is projected to become dire within the coming decades, with scientists predicting that by 2050, medicine could potentially come full circle to the pre-antibiotic era, with microbes which are completely and totally resistant to every antibiotic known to medicine

The First Industrial Revolution, Second Industrial Revolution, and Impending Third Industrial Revolution

Third-Industrial-RevolutionIndustrial revolutions require 3 key components to occur, 3 defining technologies which emerge and converge to create the catalyst needed to usher in a new era of human achievement and progress. The first component is new methods of communication technologies to make communication more efficient and to manage economic and social life (e.g. video conferencing), the second is new sources of energy to more efficiently power economic and social life as well as governance (e.g. renewable energy technologies), and the third is new modes of mobility and logistics to more efficiently move economic and social life as well as governance (e.g. on demand ride sharing). The First Industrial Revolution was caused by the discovery of a new source of energy; coal. Coal powered the new communications medium, the steam powered press, and a new logistics structure via the locomotive railway. When these 3 technologies converged, much of the world (e.g. the whole of Europe) changed seemingly overnight. As a direct consequence of the First Industrial Revolution, business models moved toward market capitalism and major city hubs began developing ushering in the modern world format. The Second Industrial Revolution occurred in the U.S. during the late 19th and early 20th century with the advent of the telephone in the late 19th century, and the advent of radio and television in the early and mid 20th century. At approximately the same time that the telephone and telecommunications networks were being developed, the U.S found a new source of energy which was oil in Texas, United States of America. Henry Ford compounded this discovery by producing a cost effective combustion engine, powered by oil which provided new logistics and mobility technology. The Second Industrial Revolution however is now fading away due to the impact it has had upon the Earth’s climate and humanity is now upon the precipice of a Third Industrial Revolution. The internet has become the new communication medium, millions of people are now adopting renewable energy (e.g. solar, wind, geothermal etc.) and it is predicted that when autonomous vehicles connect to smart roads, the last piece of this puzzle will be complete, thrusting humanity into its 3rd epic epoch

The Mythology of Japan Having a Closed Society Throughout History


It is a myth that Japan was completely cut off from the rest of the world throughout history, developing in a vacuum, as the official policy of the state was to close its doors, but the unofficial policy of the people was to remain open to the influence and ideas of other civilizations. The shoguns made a single exception to this rule pertaining to outsiders which was the advent of Deshima Island, a trading port that was the only place in Japan which Europeans were allowed to live and trade. Only Dutch traders were permitted access to this site due to the fact that the Dutch understood how to curry favor with influential members of Japanese society by showing tribute and swearing allegiance to the shogun, therefore becoming part of Japan’s internal feudal system. The narrow bridge between Deshima Island, Japan and Nagasaki, Japan upon the mainland was the only connection Japan had with the outside world for centuries

The Ancient Mesopotamian Law Code of Hammurabi


Dating from 1770 B.C., the most complete of ancient Mesopotamian legal texts is the Code of Hammurabi, a compendium of 282 laws which dictated the rules of commercial interactions and set fines and punishments for those found in violation of these laws. Inscribed upon a phallic piece of black obsidian, Hammurabi’s Code is depicted as receiving these laws from Shamash, the god of the sun, justice, and order, with the primary role of protecting the weak from the strong. It is written and recognized within the Hammurabi Code the first appearance of the biblical punishment of an “eye for an eye and a tooth for a tooth”. Considered by many scientists to be one of the foundational stones of world civilization, the Hammurabi Code is a mixed blessing for women, both protecting women and lowering their social rank as second class citizens. Upon the positive end, the Hammurabi Code recognized women’s basic right to own property, fundamental in its importance as it provided women legal protection in regard to the control of their dowries and inheritance. The Hammurabi Code also forbade arbitrary poor treatment and/or neglect, which meant wives who were ill or barren couldn’t be simply discarded. In divorce, women were permitted to keep their dowries, and in widowhood, women were permitted the opportunity to utilize their husbands estates as their own for the duration of their lives. The Hammurabi Code essentially recognizes Mesopotamian women as distinct persons in a legal sense, rather than property which is how most of the ancient world recognized women. Upon the negative side however, women’s economic and sexual freedoms became severely restricted, forbidden from performing any commercial activity outside of their home and supporting and legalizing the concept of the patriarchy by providing men immense autonomy over the bodies of women, meaning husbands and fathers now owned the sexual reproduction of their wives and daughters which lead to women being executed for adultery, virginity becoming a condition of marriage, and rape not viewed as a violent sexual offense against the female victim, but rather an economic offense against her father as it would cause the father to suffer a severe loss in respect to a daughters bride price as the daughter would be considered a damaged commodity. It’s unclear how these legal mandates and statutes worked at the local level as they are ideals of Mesopotamian culture, but the driving force of these laws and how they are setup and constituted is abundantly clear, allowing male authority and patriarchal notions of male honor, to become sacrosanct

The Advent of the Computer Mouse


The computer mouse became a mainstream accessory for computers shortly after Steve Jobs viewed a prototype mouse from Xerox in 1979. Jobs asked his team to create a mouse which was under $15.00, would last for 2 years, and could be used upon either a particle board desk or the jeans of a persons lap. Dean Hovey ended up creating the concept of the computer mouse by visiting a drug store after Jobs made this request in a business meeting. Hovey purchased a roll on deodorant and a butter dish and began working upon the initial design. Hovey popped the spherical applicator out of the deodorant and covered it with the butter dish to make a rollable, undulating handheld device

The Psychology Behind Why Human Beings Desire


Human beings are not born with a sense of self, as the answer to the question “who am I?” is truly the accumulation of experiences and interactions with other people. This interaction and experience creates the self-image, an idea which is built by the views and responses of other people. Modern society is comprised of a civilization which spends great time, effort, and attention acquiring and accumulating objects and possessions, often with no particular use whatsoever, collected to produce a statement of each individual, leveraging objects as an extension of the self. In a society of sentient beings, desire is an inevitability. The products which a consumerist society creates are optional but the desire is not. This drive is what makes it easy for producers to create and design products and services which are acquired by the masses, products and services which aren’t necessarily useful or needed (e.g. latest smartphone with unknown features which remain unknown until used for the first time, but this being unimportant as the end user is positive they will enjoy the features once observed) but are purchased out of the compulsion of desire. This primitive desire has created the modern concept of dynamic obsolesce. The end user is permitted to achieve a positive emotional state, for a short period of time, which quickly fades and must be replaced by something else. This character trait has been bred into the human psyche through evolution. Human beings, like all animals, compete for mates. All animals display extra resources (e.g. colorful feathers, large horns, decorative patterns etc.) to advertise for potential mates that their genes are incredibly fit for selection and reproduction. Human beings partake in this evolved display by demonstrating attributes which require extra energy and natural resources which aren’t required to be genetically fit, which the human mind responds to regardless of the features usefulness (e.g. high heeled shoes and makeup, fast automobiles, designer clothing and accessories like handbags etc.). Manufacturers of these types of products intuitively understand and therefore successfully hijack the concept of status, one of the most fundamental determinants of human behavior. Producers of products and services tap into the preoccupation human beings have with what others think as human beings are effectively animals seeking social stature and prestige. Because of this, human beings prefer objects to be new, flamboyant in their display, and convenient

The Worlds First Ride Sharing Program


The Dutch love of the bicycle lead to the advent of the first bicycle sharing program in 1965 which was started by John Lennon and Yoko Ono who brought attention to the fact that Luud Schimmelpennink (pronounced “lewd shim-el-pen-ick”) who purchased a bike, painted it all white, and then left it in the middle of Amsterdam for anyone who wanted to ride it, with the expectation that they would return it. Eventually, more and more white bicycles were found around the city of Amsterdam for users to pick up and use and then leave for somebody else to enjoy once they had reached their destination

Sweden’s Major Contributions to Vehicular Safety Standards Worldwide


In 1959, Nils Bohlin (pronounced “neels bow-leen”) created the 3 point seatbelt while working for Volvo, an invention which Volvo intentionally designed to be patent free so that the advent could be utilized and implemented globally in a concerted effort to save lives everywhere. This was one of the first examples of open source technology in business and manufacturing. It’s been estimated that the seatbelt has saved more than 1,000,000 (1 million) lives over the past 40 years as of 2020. Swedish company Autoliv (pronounced “ow-tow-leeve”) furthered this pursuit towards safety by creating the seatbelt pre-tensioner which instantaneously reels in seatbelt slack during a vehicular accident and has also helped to design newer, better airbag systems and advanced artificial intelligence automobile visual systems

The Guaranteed Path to Heaven for Muslims and its Relation to Najaf, Iraq and Celebrity Undertaker Ali al-Amiya


Shia Muslims believe that to be buried in Najaf, Iraq, guarantees a path to heaven, with many industries related to death found within the city including the manufacturing and provision of burial plots, caskets, grave stones, and grave digging, ironically with those involved, making a living from death. The largest cemetery in the world is Wadi al-Salam which means the “Valley of Peace” in Arabic, with over 5,000,000 (5 million) gravesites. Ali al-Amiya, the most famous person within this Iraqi industry, works at this cemetery as an undertaker. Traditionally, caskets are white, but al-Amiya started the trend of using black caskets. al-Amiya is famous because of his distinctive tombstone designs, innovative funeral services, and because of the way he digs graves. al-Amiya has over 800,000 followers upon Facebook and has a catchphrase that is known by all Iraqis which is, “who is going to bury you like the Prophet Mohammad? Ali al-Amiya!”. al-Amiya offers heavily discounted or free burials for martyrs and the extremely impoverished. al-Amiya is vehemently disliked by most other undertakers within the industry and has nearly been a victim of multiple sting operations in which prostitutes were sent to solicit him as well as physical threats upon his life and his family’s. Modern, progressive thinking undertakers like al-Amiya face resentment in Iraq but the rise of social media has helped combat this animosity. In 2017, a survey found that 85% of Iraqis use social media, specifically Facebook which has demonstrated instrumental in altering public perceptions of Islamic burial traditions

The 18th Century Gin Craze and it’s Association with Murder


Gin was highly consumed in poorer areas of London, England as it was a cheaper alternative to beer. Gin was unregulated during the early 18th century, and was often badly distilled and filled with harmful compounds like oil of vitriol which is similar in construct to modern day turpintine, sulfuric acid, and methylated spirits. By 1750, gin consumption was at its peak, with the city of London consuming 11,000,000 (11 million) gallons per year. In the poorest areas of London, specifically upon the east end, it was not uncommon for everyone in public to be permanently drunk; an analogue to the modern day crack cocaine epidemic of the 1980’s. All members of society consumed gin including men, women, and children, with many cases exhibiting severe addictive traits as was the case with Judith Darfour, who took her child into a heath, murdered them to sell their petticoat clothing and acquire more gin, then attended work later that day as if nothing had occurred. Gin related crime soared and Mothers Ruin which refers to “women who killed their family members to acquire funds for gin” was responsible for the deaths of thousands of men, women, and children. When the death rate climbed higher than the birth rate, the British government was forced to intervene, outlawing small gin distilleries and ending the era referred to as the “Gin Craze”