It is a common misconception that transgender athletes who transition from male to female have the same sexual dimorphisms and therefore the same athletic capabilities and baseline statistics as cisgendered women when competing within athletic competition. Cisgender males on average have 40% more upper body muscle/strength than cisgendered women and 30% more lower body muscle/strength than cisgendered women, although these are mere approximations which span the entire world population which is why this is not always the case. Female hormones can reduce these advantages by 5% – 10% within the human body of elite athletes, but it is at the current time, as of 2023, impossible to completely reverse the advantage of biological male puberty for transgender male to female athletes. Surprisingly, hormone therapy rapidly reduces hemoglobin levels to that of cisgender women however all other baseline statistics remain relatively the same post transition when using hormone replacement therapy. Even after 36 months of treatment, virtually all other baseline levels are higher than the average cisgender female. These discoveries suggest that physical strength may be preserved in transgender women during the first 3 years of hormone replacement therapy. It should be noted, if the athlete does not go through male puberty, these male hormone induced advantages do not apply. This is because these traits are largely associated with testosterone but not entirely
Category: Endocrinology
The Origin of the Use of Analgesia While Giving Birth
Analgesia was not an option while giving birth until the mid 19th century as pain was believed to be a crucial part of the birthing experience. In 1591, Euphemia Maclean, a woman from Edinburgh, Scotland requested analgesia during the birth of her twins and was burned at the stake for this request. Analgesia started with Queen Victoria who used chloroform for the birth of her 8th child Leopold. It was Victoria’s experience that she told to others which made the practice catch on so quickly as Victoria felt that analgesia was an amazing invention which helped her immensely. In the 1950’s, the no medication approach swung back into fashion with Dr. Grantly Dick-Read, the first modern physician to suggest against analgesia as he believed the pain of childbirth to be psychological
The First U.S. Presidential Vaccine Mandate
U.S. President George Washington issued the first presidential vaccine mandate, requiring all soldiers within the continental army to become vaccinated against smallpox on February 5, 1777. 90% of deaths during the American Revolution were due to disease, with smallpox being the most prevalent and difficult pathogen for the military to control. Immunization was viewed as an achievable solution to a virtually insurmountable problem as death from smallpox plunged from 30% to 2% after a becomming immunized. Vaccination, or “variolation” as it was referred to during the era, was achieved by taking a small piece of an active smallpox sore from an infected person, and then introducing it to the person being inoculated via inhalation or by scratching their arm and introducing the virus by touch. The mandate, although initially detested, became highly successful in its pursuit of lowering soldier mortality rate, with 40,000 soldiers vaccinated by the end of 1777
The Reason Alcoholic Hangovers are Unpleasant
A hangover at its most basic premise is caused when the body does not have enough water to run its citric acid cycle (also referred to as “CAC”, “tricarboxylic acid cycle”, “TCA cycle”, and/or “Krebs cycle”). This is exactly the process which occurs when a person dies of thirst. Although hangovers are typically not dangerous, this is part of the reason why they feel so uncomfortable
The Study of Bacteriophages in Antibiotic Research and Why They May be the Next Major Scientific Breakthrough
Bacteriophages, which are viral infections that reproduce to target and kill bacteria, were studied in Eastern Europe during the 1950’s by countries which did not have access to western medicine, including antibiotics. In 1 milliliter of sea water, billions of phages are present, with countless different varieties. Phages have tendril like appendages which are used to probe and identify hosts, clinging onto them, then forcing its own deoxyribonucleic acid down into the bacterial host. When this genetic code is introduced, it destroys the bacteria as a direct result. This leads to a chain reaction as hundreds more are produced each time this instance occurs, copies which then fledge out and find hosts of their own, building populations exponentially and wiping out bacterial infections completely. Bacteriophages were found prior to chemical antibiotics but when Penicillin was discovered, because it is so easy to develop and administer, chemical antibiotics became the clear path of choice in medicine with scientists not realizing the severity of this error until decades later. Antibiotics are often broad spectrum which is another reason antibiotic research overshadowed bacteriophagic research as different phages affect different bacteria and are therefore not broad spectrum. Because phages are self-replicating like bacteria, they have the ability to completely annihilate all bacteria presented before them in the same way that bacteria have the ability to totally annihilate their own host as well. Because of this, bacterial infections can be knocked out with 100% efficacy in all cases, regardless of the severity of the the infection, provided the correct phage is alotted enough time to do so. This is a task antibiotics often struggle to achieve and even if achieved, cannot be guaranteed in perpetuity as reinfection or resistance can occur at any time
The Four Ancient Greek Concepts of Love
The Ancient Greeks had 4 terms for love. The first term, “philia” (pronounced “feel-ee-ah”), refers to “affection which grows from friendship”. The second term, “storgē” (pronounced “stor-gay”), refers to the “kind of love one has for a grandparent or sibling”. The third term, “érōs” (pronounced “air-ohs”), refers to “romantic love, the uncontrollable urge to say “I love you” to another person”. The fourth and final term, “agápē” (pronounced “ah-gah-pay”), refers to “steadfast love as an action, the kind of love to take care of a partner in their elder years as they decline further and further”