The Discovery of Bacterium Causing Stomach Ulcers

For decades the medical community believed gastric ulcers were directly related to stress with the only options for relief being antacids and surgery. In the early 1980’s, Australian physicians Barry Marshall and Robin Warren discovered through biopsies of gastric ulcers, that nearly all were overrun by helicobacter pylori bacteria. Helicobacter pylori only seems to infect humans, as studies performed upon pigs and rats were unsuccessful as these animals were unable to contract the bacterium. Marshall decided to infect himself and within 5 days of doing so, he started running to the bathroom each morning to throw up. Tests demonstrated that Marshall had gastritis, a precursor to an ulcer. Marshall took antibiotics and was cured, proving once and for all that ulcers are caused by bacteria not stress. In 2005, Marshall and Warren won the Nobel Prize in Medicine for their findings

The First U.S. Presidential Vaccine Mandate

U.S. President George Washington issued the first presidential vaccine mandate, requiring all soldiers within the continental army to become vaccinated against smallpox on February 5, 1777. 90% of deaths during the American Revolution were due to disease, with smallpox being the most prevalent and difficult pathogen for the military to control. Immunization was viewed as an achievable solution to a virtually insurmountable problem as death from smallpox plunged from 30% to 2% after a becomming immunized. Vaccination, or “variolation” as it was referred to during the era, was achieved by taking a small piece of an active smallpox sore from an infected person, and then introducing it to the person being inoculated via inhalation or by scratching their arm and introducing the virus by touch. The mandate, although initially detested, became highly successful in its pursuit of lowering soldier mortality rate, with 40,000 soldiers vaccinated by the end of 1777

The Study of Bacteriophages in Antibiotic Research and Why They May be the Next Major Scientific Breakthrough

Bacteriophages, which are viral infections that reproduce to target and kill bacteria, were studied in Eastern Europe during the 1950’s by countries which did not have access to western medicine, including antibiotics. In 1 milliliter of sea water, billions of phages are present, with countless different varieties. Phages have tendril like appendages which are used to probe and identify hosts, clinging onto them, then forcing its own deoxyribonucleic acid down into the bacterial host. When this genetic code is introduced, it destroys the bacteria as a direct result. This leads to a chain reaction as hundreds more are produced each time this instance occurs, copies which then fledge out and find hosts of their own, building populations exponentially and wiping out bacterial infections completely. Bacteriophages were found prior to chemical antibiotics but when Penicillin was discovered, because it is so easy to develop and administer, chemical antibiotics became the clear path of choice in medicine with scientists not realizing the severity of this error until decades later. Antibiotics are often broad spectrum which is another reason antibiotic research overshadowed bacteriophagic research as different phages affect different bacteria and are therefore not broad spectrum. Because phages are self-replicating like bacteria, they have the ability to completely annihilate all bacteria presented before them in the same way that bacteria have the ability to totally annihilate their own host as well. Because of this, bacterial infections can be knocked out with 100% efficacy in all cases, regardless of the severity of the the infection, provided the correct phage is alotted enough time to do so. This is a task antibiotics often struggle to achieve and even if achieved, cannot be guaranteed in perpetuity as reinfection or resistance can occur at any time

The Negative Effects Associated With Condom Usage During Sexual Intercourse

Many experts feel as though they cannot talk about the negative aspects of condom usage to promote safe sexual intercourse, however scientifically speaking, there are several negative effects which can be incurred when doing so. The reason these individuals with specific expertise in sexual reproduction, biology, anatomy, and/or physiology do not discuss these issues is because of the fear of spreading misinformation because it’s already difficult to get people to consistently use prophylactics during intercourse, dumping negative information into the public would most likely if not most definitely cause adherence statistics to plummet. With that being said, condom usage can and does on occasion cause 3 different bacterial strains to become present within the vagina, causing erythema both inside the vagina and upon the vulva. The infection is more likely to occur after intercourse has commenced. This rational argument is the most widely used argument within the adult entertainment industry to avoid condoms by performers both male and female. These individuals are tested monthly, sometimes even biweekly for every known kind of sexually transmitted infection and disease, which is why many within the field argue that condoms are an unnecessary risk for them to partake in as their ability to perform sexual acts is their primary source of income and if this is hindered, the consequences could be financially detrimental

The Rationale Why Pharmaceutical Organizations are Not Incentivized to Develop Antibiotics and Why This is Dangerous for the Worlds Next Pandemic

Within 5 short years of release, approximatly 20% of antibiotics become subject to resistance from bacterial pathogens which means that antibiotic proliferation is chronologically limited within its life expectancy. Coupled with this, if an antibiotic is highly effective, the scientific and medical community often rally against its usage so that such a tool can be saved in reserve for a global bacterial pandemic. In either scenario, return upon investment is less than what it would be with a different class of medication (e.g. selective serotonin re-uptake inhibitor, statin, hypnotic etc.) which is why pharmaceutical organizations are less interested in research and development dedicated to antibiotic medicine in favor of other, more profitable medication categories. This lack of investment however is myopic and will inevitably backfire upon the pharmaceutical industry as a whole if new antibiotics are not developed because medications used to treat cancer will become less in demand due to the fact that cancer patients are highly likely to acquire an infection during treatment when their immune system is comprised, with this infection often killing the patient if antibiotic solutions are not available. This would expectedly lead to a sharp decline in cancer medication treatment and subsequently pharmaceutical sales of related medications as patients would be likely to adopt living the rest of their life as fully as possible and forgoing treatment as they would be damned if they accept the cancer treatment and develop an infection which kills them but also damned if they don’t accept the treatment and let the cancer run its course which is almost always fatal. To provide comparison of the research, development, and manufacturing contrast between oncology medications and antibiotics, as of 2020, there are currently 800 medications in development for cancer and hypertension whilst only 28 antibiotic medications undergoing that same research phase and development process, with 2 of these antibiotics expected to become fully developed and able to reach the market and patients. The last new antibiotic class, lipopeptides, were introduced in 1984 with a gap referred to as an “antibiotic void” occurring during the 1990’s, 2000’s, 2010’s, and now moving into the 2020’s. The urgency of this threat is projected to become dire within the coming decades, with scientists predicting that by 2050, medicine could potentially come full circle to the pre-antibiotic era, with microbes which are completely and totally resistant to every antibiotic known to medicine

The Spanish Flu Pandemic of 1918 in London, England

At the end of World War I, soldiers coming back to London, England from the Western Front brought with them a particularly infectious version of influenza referred to as the “Spanish Flu”. Exact metrics are unknown because of poor data collection during the early 20th century but an estimated 50,000,000 (50 million) deaths occurred, 3x as many people than that which died during the entire span of World War I. Spanish Flu had its most devastating blitzkrieg upon London in the autumn of 1918, as thousands civilians and soldiers, weakened from 4.5 years of war, became ill within a few short days of Armistice Day. Spanish Flu works quickly to destroy the lungs of healthy victims, with those who contracted the pathogen feeling fine in the morning and often found dead, later that same evening. In 1918, 320 people died of Spanish Flu in London, but during 1919, Spanish Flu had a resurgence and exploded in severity with 16,000 – 23,000 people killed, a surge which caused a shortage of gravediggers and coffins, classifying Spanish Flu as the worst epidemic in living memory. The Spanish Flu outbreak came to an end in May of 1919 once enough of the British population had experienced the infection and either been killed or having survived, becoming immune to the point that the disease could no longer be passed through hosts efficiently enough to continue its spread

The 18th Century Gin Craze and it’s Association with Murder

Gin was highly consumed in poorer areas of London, England as it was a cheaper alternative to beer. Gin was unregulated during the early 18th century, and was often badly distilled and filled with harmful compounds like oil of vitriol which is similar in construct to modern day turpintine, sulfuric acid, and methylated spirits. By 1750, gin consumption was at its peak, with the city of London consuming 11,000,000 (11 million) gallons per year. In the poorest areas of London, specifically upon the east end, it was not uncommon for everyone in public to be permanently drunk; an analogue to the modern day crack cocaine epidemic of the 1980’s. All members of society consumed gin including men, women, and children, with many cases exhibiting severe addictive traits as was the case with Judith Darfour, who took her child into a heath, murdered them to sell their petticoat clothing and acquire more gin, then attended work later that day as if nothing had occurred. Gin related crime soared and Mothers Ruin which refers to “women who killed their family members to acquire funds for gin” was responsible for the deaths of thousands of men, women, and children. When the death rate climbed higher than the birth rate, the British government was forced to intervene, outlawing small gin distilleries and ending the era referred to as the “Gin Craze”

The Ebola Contagion Epidemic of 2014

In late December of 2013, children of Meliandou, Guinea in West Africa found hundreds of bats nesting in a hollowed out tree. The children had no way of knowing that bats are the suspected carriers of the ebola virus. The children lit a fire and the bats scattered from the tree, allowing the children to catch and consume these bats as a source of protein. It is suspected that this is what triggered the ebola epidemic of 2014. Villagers originally thought that the illness spreading was due to witchcraft but authorities quickly identified the outbreak as ebola in an attempt to quarantine and curb the spread of the infection. Illness rapidly spread across the forest region of Guinea as those who were ill came into contact with healthcare workers whilst seeking medical attention which lead to surrounding areas becoming impacted. For 3 months, the symptoms of ebola were mistaken for cholera and malaria, which is why the contagion was unable to be controlled and halted. The problem quickly spiraled out of control with thousands becoming ill and a total of 11,315 deaths across 6 countries including Guinea, Liberia, Sierra Leone, Nigeria, Mali, and the U.S., however the U.S. faired best with only 49 of the total deaths. The government of Guinea had no idea how to respond as all previous ebola outbreaks had occurred over 1600 kilometers away, however the relief group Doctors Without Borders had decades of experience and were able to be flown in in and effort to curb the spread of the pathogen. Within 48 hours of arrival, Doctors Without Borders had setup a field hospital in the village of Guéckédou, Guinea, the epicenter of the ebola outbreak. Past outbreaks have taught physicians that the best counter attack is to isolate the ill, monitor those who have had contact with the sick, and safely bury the dead. Due to the scale of the problem and the fact that it was not isolated to a single group or village, Doctors Without Borders did not have the resources to contain this potential global threat which is why the World Health Organization became involved, a group which is part of the United Nations and has access to the best and most expensive resources in the world, with a mandate to help governments coordinate responses to outbreaks. The main problem facing the World Health Organization is that the organization itself does not take precedent nor command of any medical situation as it is the country which is dealing with a contagion that must take this lead. Due to the fact that Guinea is a poor nation with few resources, grabbing hold of the ebola outbreak was exceedingly difficult as physicians did not have proper oversight by those in power with ebola experience, the governments of affected nations were some of the poorest in the world, and the World Health Organization was in the process of downsizing, causing the entire process to become more complicated and convoluted as decision making was scattered and often conflicted. This created the perfect storm for ebola to quickly spread across the African continent and into the western world. The government of Guinea accused Doctors Without Borders of sowing panic among the public which further elevated tensions between the 3 organizations involved. Guinea’s Ministry of Health demanded that only laboratory confirmed cases be counted towards the total ebola death count which tied the hands of physicians and their governing organizations as this act downplayed the importance and severity of just how severe the ebola outbreak truly was which lead to further contamination as the public did not treat the disease with the full gravitas of what it demanded. It is believed that this single political act is what allowed ebola to jump across borders, starting with the neighboring country of Sierra Leone as residents of both states are permitted to freely cross the borderline of either nation as often as they wish, a political policy which should have been suspended during a period of mass outbreak. Rumors of foreign physicians killing impoverished residents with syringes helped inflame already growing tensions between healthcare professionals and the general public which made working with infected or potentially infected individuals exceedingly difficult for healthcare practitioners. The corpse of an ebola victim is highly infectious but in West Africa, it is customary for friends and family to spend hours with a person after death, washing and preparing them for their burial (e.g. cutting nails and braiding hair etc.). The sudden cessation of the ability to perform this ritualistic act deeply embedded within West African culture fueled even more resent from the public which caused mass rioting and chaos to ensue, endangering the lives of those who were there to help, made worse by the lack of education, language barriers, and cultural barriers already present. It is theorized that this cultural convention played a major and definitive role in the spread of the ebola virus, as mourners often touch the body during the funerary procession. It is believed by the inhabitants of West Africa that if a body is not laid to rest properly, the ghost of that person will return to haunt the people of the village which is why this ritualistic process is so deeply embedded and revered in this region of the world. The government of Guinea had no method of contact tracing, that is to say, there was no method in place to monitor those who had come in contact with ebola victims which allowed for hundreds of cases to go undetected. The World Health Organization debated whether or not to declare an international health emergency which would have acted as a global distress signal, enacting the aid and preparation for a counter attack from many of the worlds most industrialized nations (e.g. the U.S., Canada, Japan etc.). Officials worried that declaring a global emergency would create panic which would only help exacerbate the issue as many countries, particularly in Europe and the Middle East, could potentially close their borders in an effort to ensure the ebola virus remained exclusively in Africa, the worlds most impoverished continent. To exacerbate the already fevered tensions between government officials, healthcare workers, and the public at large, an event transpired which threw much of the West African population into a panic. In Kenema, Sierra Leone, a woman purporting herself as a nurse, began shouting in the center of the cities most populated marketplace, “there is no ebola! I say to everyone it’s not real. Ebola is not real. It’s cannibalism”. The crowd started to cry for others to come over, to hear the supposed confessions of a nurse stating that physicians are killing innocent people for the consumption of their bodies as meat. The tide quickly changed and the crowd began turning upon the healthcare staff present, throwing stones, giving chase, and threatening their lives, forcing the evacuation of virtually all physicians, nurses, and other interdisciplinary healthcare personnel. This woman was not a nurse, rather she was a person afflicted with mental illness, but her impact greatly exacerbated an already uneasy hoard of people, so much in fact that law enforcement were forced to attend and disperse tear gas to control the ire of the group. By this point, the ebola outbreak had claimed more than 800 people across 3 countries. Physicians urged the World Health Organization to declare an international emergency however organization officials refused to do so because it was believed that this act would only add fuel to an already raging and seemingly out of control inferno of illness and chaotic unrest. It was at this point that the ebola outbreak rose to a new level when an infected Liberian traveled to Nigeria, Africa’s most populous nation, and the U.S., forcing the World Health Organization to declare an international emergency, by holding a press conference given by Dr. Margaret Chan, the Director-General of the organization itself. A high ranking team was assembled and deployed to Geneva, Switzerland in response, devising and enacting a plan to employ thousands of western medical professionals in an attempt to curb an infectious outbreak which was growing by this point at an exponential rate. The outbreak was so beyond the reach of control by this time that it had spread across a broad geographical area, unlike anything ever witnessed in modern memory. The main caveat to the curated plan was that the World Health Organization did not have a standing force of physicians, nurses, laboratory technicians, and other various healthcare practitioners, ready and willing to help serve in the fight to combat such a prevalent contagion, nor did they have the budget to build one. The only option available was to appeal to the worlds wealthiest nations, persuading and to an extent pleading with trained and qualified healthcare workers who were willing and able to travel abroad and join the collective effort. This endeavor would take time as acquiring a team en mass is an extraordinarily ambitious goal to accomplish. Rioting continued to occur with some hospitals being overrun by disillusioned citizens who were angry, frightened, and frustrated enough to allow every patient under quarantine to run back into the village, allowing for the proliferation of the disease to spread even further. Governments attempted to respond by sending in military squadrons to guard sanctioned quarantined buildings in an effort to help contain an outbreak which for all intents and purposes was completely out of control and continuing to spiral into calamity. Citizens were killed both by soldiers with firearms as well as infection as those who were infected were in the streets, amongst the general populous. Doctors Without Borders began constructing ELWA 3 (pronounced “ell-wah-three”), the largest Ebola treatment center ever built, but despite their best efforts, the facility was not large enough to contain the sheer volume of people who needed medical aide. It was at this point that Doctors Without Borders made an urgent plea directed solely towards the U.S to provide thousands of soldiers immediately in order to help isolate and treat patients. Dr. Tom Frieden, Director of the Center of Disease Control, traveled to the ELWA 3 clinic in Monrovia, Liberia to see first hand, just how bad the epidemic was. Frieden recounted his experience by stating that he witnessed a “level of devastation that I have never seen” and that he was “seeing a country essentially in free fall and knowing, knowing with certainty that no matter what we did, it was going to get a lot worse before it got better”. Frieden called then President Barack Obama stating that the outbreak was expanding at an exponential pace, doubling every 3 weeks, resulting in a tripling of results with every month of delay instituted. Obama responded by implementing emergency U.S. aide, sending thousands of soldiers and medics, 10 months after the outbreak had initially begun, in an attempt to quell and eradicate the spread of this viral disease. Other industrialized nations soon followed suit and the United Nations created a new emergency mission for the World Health Organization and other related agencies to coordinate the response. Work began on the ground with the building of new treatment centers and training to teach those deployed how to properly bury affected victims. Despite these monumentous efforts, the ebola virus was still ahead of the response and threatened to spread beyond African borders. Shortly after this humanitarian response, cases in Monrovia began to sharply decline, but experts believed that the downward trajectory would bounce back in an even more dramatic resurgence as people were now staying home due to the events which had recently transpired across the African continent, allowing them to infect more people than if they had been under isolation. Fortunately, the drop in reported cases remained steadfast in its declination as Liberians stopped trying to nurse their sick and started burying the dead in an appropriate and safe manner. Liberians began to understand that the ebola virus was so drastically deadly that previous cultural customs had to be shelved for the time being so that the disease could be expunged and life could return to normal for those who had survived. Thousands more continued to die across West Africa, but the changed behavior of West Africans and the massive international response gradually turned the tide of the war

The Danger of Air Pollution Gaining Access to the Brain

air-pollution

The reason pollution has a metallic taste and scent and that it burns the eyes when exposed to it is because the particles of air pollution are tiny enough that they can travel through nerve cells, and gain direct entry to the brain, where the olfactory bulbar meets the frontal cortex, as there is no blood-brain barrier at this point. The body protects itself through the blood-brain barrier, which means that particles within the bloodstream, cannot get directly into the brain. This system has a slight flaw however as the nose acts as a direct conduit for incredibly tiny particles to bypass this security mechanism

The Scientific Study of Consciousness After Decapitation In Rodents

laboratory-rat

Brainwave activity in laboratory rats has been measured after decapitation. Scientists have determined that the brain stays conscious for 4 seconds after decapitation. Laboratory rat brain cells could theoretically start working again if intervention is quick enough supplying the brain with adequate oxygen and glucose