Analgesia was not an option while giving birth until the mid 19th century as pain was believed to be a crucial part of the birthing experience. In 1591, Euphemia Maclean, a woman from Edinburgh, Scotland requested analgesia during the birth of her twins and was burned at the stake for this request. Analgesia started with Queen Victoria who used chloroform for the birth of her 8th child Leopold. It was Victoria’s experience that she told to others which made the practice catch on so quickly as Victoria felt that analgesia was an amazing invention which helped her immensely. In the 1950’s, the no medication approach swung back into fashion with Dr. Grantly Dick-Read, the first modern physician to suggest against analgesia as he believed the pain of childbirth to be psychological
Category: Pharmacology
Botulism Toxin (Botox) Disabling Portions of the Human Brain Related to Emotion
Because human beings interpret emotions by mirroring one another, botulism toxin, more commonly referred to by the brand name “Botox”, when injected into the forehead, alters brain activity connected with various emotional states. The temporary paralysis of facial muscles from the use of Botox disables a person’s ability to mirror the person(s) they are interacting with. It also hinders their ability to read and interpret the facial expressions of others. Surprisingly, this information is being leveraged within studies of depression and patients diagnosed with borderline personality disorder, as it is believed that temporary paralysis of the forehead may help aid those who are experiencing clinical depression and/or a borderline personality disorder
Gender Reassignment Surgery: Male to Female
The reason gender reassignment surgery is possible is because all human beings begin life with the same anatomy, with the ovaries starting from the gonadal ridge, becoming testicles if they drop and remaining as ovaries if they do not. In addition to this, the clitoris is effectively a short penis as both genitalia are physically and anatomically identical (e.g. nerve ending bundles, interior connection and placement, sexual function etc.). When male anatomy is transitioned into female anatomy, a reversal of embryology occurs. When a biological male transitions to become female, during surgery, the scrotal skin is excised after which it is opened to form the labia majora and labia minora, and part of it is utilized to line the new vaginal cavity. The testicles are removed in their entirety and the cliterous is formed using the head of the penis which allows the cliterous to function as it does upon the body of a biological female, with most patients able to orgasm post surgery once healed. The volume of erectile tissue is decreased as the penis is effectively folded over, but because the nerves and arteries remain attached, sensation remains. Once the cliterous is sutured into place, the vaginal tunnel is created which is the most difficult aspect of the entire surgical procedure. A space is created between the bladder and the rectum which is difficult as both structures contain significant blood supply and injury to these systems can cause major complications. A skin graft from the scrotum is then set in place onto a cylindrical mold and sutured around it once the cavity is produced so that it can be implanted. Hair follicles are obliterated as they will continue to grow internally if not removed which would cause further complications. The mold used is an approximation of the average male penis which allows surgeons to create a cavity large enough to allow for sexual intercourse if desired. Small cosmetic details are taken care of after which the patient is sutured and migrated out of the operating theater so that they can be left to rest and reawaken after the anesthesia administered wears off
How Methamphetamine Works Within the Human Brain
Methamphetamine causes a rush of dopamine to be released which provides euphoria with a rapid onset. Typically the brain has a dopamine level of 50 – 75 units, but when methamphetamine is present within the system, this value bounds to become 900 – 1250 units, larger than any other drug. Over time, methamphetamine destroys the brain’s ability to produce dopamine naturally, allowing levels to fall below baseline, causing a person who uses the substance to crave more and more to feel normal and balanced. To provide a scale of reference, cocaine typically produces dopamine levels of 100 – 350 units
The Most Important Intervention to Avoid Suicide During a Mental Health Crisis
In the U.S., most firearm related deaths are not homicides but rather suicides, and more people commit suicide by firearm then by all other methods combined. The timeframe of a suicidal crisis is typically 1 – 10 minutes in duration, and having a firearm at close reach increases the likelihood of a successful suicide attempt by 95%. If a firearm is not present during a moment of suicidal crisis, and another method is used to attempt suicide, this statistic plunges dramatically to become a 5% – 10% success rate. This is important as the means by which someone takes their life matters. Living in a firearm free home is a critically important aspect of suicide prevention for those who are at risk. It is recommended that during a crisis event, all firearms are unloaded and taken to a trusted friend, with all prescription, over the counter medications, and household poisons (eg. Draino etc.) locked away as well
The Etymology of the Gaelic Spirit Whisky
The Gaelic term “uisce beatha” (pronounced “ish-kah bahh”) translates to mean “water of life” and was originally intended to be used as the name for Scottish whisky. The term was shortened to “uisce” (pronounced “oosh-key”) which is where the English term “whisky” is derived
How Ritalin Acquired its Name
Methylphenidate, more commonly known by its brand name “Ritalin”, was developed in 1944 by Swiss scientist Leandro Panizzon. Panizzon created the medication in part as he wanted his wife Marguerite to become more energized, play better tennis, lose weight, and help improve her hypotension. Panizzon created the term “Ritaline” (pronounced “ree-tah-lean”) for his newly invented medication, named as such for his wife Marguerite (pronounced “mar-gah-reet”) as Marguerite always referred to herself using the shortened version of her name, “Rita”. When Chemische Industrie Basel, more commonly known by the acronym “CIBA”, the company which owned the research, released methylphenidate into the marketplace, the “e” was discarded from “Ritaline” to create “Ritalin” (pronounced “ree-tah-lin”)
The Argument Against Stem Cell Research and Why This Will No Longer be a Problem in the Future
The reason stem cell research is controversial for some is because it is viewed as damaging and harvesting from one life to help another. This argument may be obsolete in the future as scientists are now discovering ways to create stem cells from cells within the body (e.g. skin cells etc.). The traditional method to create a stem cell was to take a skin cell, remove the deoxyribonucleic acid from its nucleus, placing it into an egg which does not have deoxyribonucleic acid but is capable of changing deoxyribonucleic acid, turning it into a stem cell which has the patients genome ascribed unto it. The new method involves placing 4 genes into the nucleus of the skin cell and allowing time to pass, as the genes reorganize the deoxyribonucleic acid so that it begins to appear as stem cell deoxyribonucleic acid, which changes the skin cell and causes it to shrink, losing its outside, converting it into an embryonic stem cell with the only difference between this method and traditional embryonic stem cell creation method being that this technique contains the deoxyribonucleic acid of the patient it is being inserted into. The 4 genes inserted into the cell create 4 proteins which exist naturally within an egg. These proteins trigger the skin cell deoxyribonucleic acid to arrange itself identically to how it would within an embryonic stem cell. Scientists refer to this type of cell as “induced pluripotent stem cells”, commonly abbreviated as “IPS cells”. Ideally, scientists want induced pluripotent stem cells to function identically to natural embryonic stem cells, avoiding the creation of unwanted cells which can lead to cancer. Researchers have discovered that some laboratory created stem cells fail to carry out the task provided and worse yet, some cause cancer to develop. Scientists are currently pursuing 2 paths to alleviate this problem, the first being the attempt to develop induced pluripotent stem cells which function identically to natural embryonic stem cells and the second being to create a system to recognize which induced pluripotent stem cells will fail in an effort to exclude these cells from being inserted into the human body
The 4 Types of Demonic Activity Recognized by the Catholic Church for Exorcism
The Catholic Church recognizes 4 distinct types of demonic activity which include Demonic Infestation (e.g. the presence of evil within an object or at a specific location), Demonic Vexation (e.g. person who experiences physical attacks from a demon), Demonic Obsession (e.g. person who experiences mental attacks from by a demon), and Demonic Possession (e.g. person who has had their body hijacked by a demon with the demon utilizing the victim’s body as though it was their own). Cases of formal exorcism in which a person believes they are possessed by a demon are rare with high ranking Catholic clergy typically seeing 1 – 2 dozen during their career, however cases of Demonic Infestation, Demonic Vexation, and Demonic Obsession are quite common with high ranking clergy typically observing thousands of these cases during that same time span. Although exorcisms are portrayed in media as relatively short exercises, it is not uncommon for those who believe they are possessed to have the exorcism ritual last for days, and for the possession believed to be present to last months or years in duration
The Coca Leaf Extraction Process to Manufacture Cocaine
The cocaine extraction process is complicated but begins with workers shredding the leaves of the coca plant into fine particulate with machinery (e.g. weed trimmer etc.) after which cement powder is added, then sulphuric acid dissolved in water, with the leaves then being placed into an oil drum and doused with gasoline. The mixture is left to sit for an extended period of time so that the cocaine itself can be extracted from the coca leaf. The oil drum mixture is stirred continuously using a large rod and then poured through a filter into another container where battery acid is introduced. The battery acid is sulphuric acid making it similar to the first few steps but it is slightly different as it is diluted with water to become no greater than a 37% concentrate. Battery acid helps to separate the cocaine liquid from the gasoline, with 90% of the barrel being gasoline and 10% at the bottom being pure liquid cocaine. Because the gasoline and liquid cocaine have different specific densities, plantation workers place a hose into the bottom of the barrel so that the liquid cocaine can be extracted, either using a pump or gravity by manually sucking on the hose until liquid cocaine starts flowing through. Pure liquid cocaine is clear like water, and has an acidic, bitter, strong taste. Sodium bicarbonate is then added as it helps to eradicate the excess gasoline and battery acid which remains and turns the liquid white. Once the liquid is dried, it begins to resemble cocaine but the process is not yet complete. The dried powder is then cooked on a stove top and stirred continuously to remove further impurities, the top layer is then removed the same way soup skin is removed with a brown colored liquid left remaining which is cocaine. The brown liquid is spread onto a baking pan and left to dry. It is this paste that is passed onto drug cartels to then be distributed internationally