The Origin of Polka Music

Polka arrived in Vienna, Austria in the 1840’s, imported from Hungary. It is believed Polka was invented by Anna Slezak, a peasant girl who invented the dance while entertaining herself by hopping around on a Spring Sunday afternoon. The term “polka” is derived from the Czech term “pulka” which means “half-step”, in reference to the dances main choreography pattern of lightly stepping from one foot unto the other

The Reason Aritifical Intelligence Differs From Traditional Software

Recently, many of the improvements made within the artificial intelligence sector have been due to the technology of “deep learning” which is also referred to as an “artificial neural network”. Traditional software is not intuitive as it simply follows a set of instructions predetermined by a programmer. If the software runs into a new problem which it has no answer prewritten for, it crashes. Deep learning is different as software can now write its own instructions instead of reading the instruction(s) of a programmer. Currently, as of 2021, deep learning is the equivalent of an all powerful, dim witted genie as it has the ability to evaluate the pixels of a photograph of a bottle of water, and can recognize with astonishing accuracy photographs of other water bottles, however it has no idea what the concept of water or the water bottle itself is, what the end user does to drink from the water bottle, what the end user needs the water for etc. This differs in human beings however as humans learn from a sample size of one, and are able to surmise the purpose of water and everything else which is relevant from witnessing it being used upon a single occasion

The Negative Effects Associated With Condom Usage During Sexual Intercourse

Many experts feel as though they cannot talk about the negative aspects of condom usage to promote safe sexual intercourse, however scientifically speaking, there are several negative effects which can be incurred when doing so. The reason these individuals with specific expertise in sexual reproduction, biology, anatomy, and/or physiology do not discuss these issues is because of the fear of spreading misinformation because it’s already difficult to get people to consistently use prophylactics during intercourse, dumping negative information into the public would most likely if not most definitely cause adherence statistics to plummet. With that being said, condom usage can and does on occasion cause 3 different bacterial strains to become present within the vagina, causing erythema both inside the vagina and upon the vulva. The infection is more likely to occur after intercourse has commenced. This rational argument is the most widely used argument within the adult entertainment industry to avoid condoms by performers both male and female. These individuals are tested monthly, sometimes even biweekly for every known kind of sexually transmitted infection and disease, which is why many within the field argue that condoms are an unnecessary risk for them to partake in as their ability to perform sexual acts is their primary source of income and if this is hindered, the consequences could be financially detrimental

The Test Subject and Scientific Experiment Which Proved the Fear Response in Human Beings Does Not Solely Reside Within the Amygdala

Justin Feinstein is one of the few scientists who have been able to study a woman who has zero fear response. To protect the woman’s identity, this subject is known only as “S.M.”, and Feinstein has had the opportunity to work with her under laboratory conditions and in real world scenarios (e.g. coffee meeting, sporting event, professional conference etc.) for the past 15 years as of 2018. S.M.’s lack of fear has had unexpected consequences within her life, as she displays no sense of typical fear induced scenarios (e.g. personal space, feeling completely comfortable being nose to nose with a complete stranger as the concept of personal space and discomfort has no meaning), heightened by the fact that S.M. does not produce typical signals of distrust when interacting with a novel person. S.M. lacks fear because she is without her amygdala, a physical trait observed in very few human beings, making S.M. one of the only people in the world to produce this physiology. S.M. has no amygdala because she has been diagnosed with Urbach-Wiethe Disease (pronounced “urr-bock vee-they”). The underlying etymology of Urbach-Wiethe Disease is still unknown but in patients with the condition, specific portions of the brain, in both hemispheres, can become subject to selective calcification which erodes the ability to function as designed. The amygdala acts as a sentry for potential fearful stimuli, and produces a response accordingly. The removal of or inability of the amygdala to work correctly results in a complete and total lack and/or loss of fear. This condition has caused S.M. considerable difficulty during her life as she has experienced dangerous interactions with those participating within the illicit drug trade. Upon one occasion, a stranger ran up to S.M., placed a firearm against her temple, and yelled “bang!”. Neighbors witnessed this event and notified law enforcement which puzzled S.M. as she did not view the event as dangerous or alarming and therefore did not expect to be contacted by the police. When the human body detects the intake of too much carbon dioxide, it can become pushed into a state of alarm. Feinstein wanted to better understand what would occur if he interfered with S.M.’s respiratory system, using 35% carbon dioxide during the first trial run. Feinstein found that S.M. was immediately fearful after a single intake breath, despite his original hypothesis of no fear response being observed. S.M. displayed an immediate and dramatic fear response with S.M. herself describing it as the “most intense fear ever felt” during her entire life. This single breath was revolutionary for neurology as it definitively proved that the amygdala is not the only region of the brain which controls and is related to fear

The Rationale Why Pharmaceutical Organizations are Not Incentivized to Develop Antibiotics and Why This is Dangerous for the Worlds Next Pandemic

Within 5 short years of release, approximatly 20% of antibiotics become subject to resistance from bacterial pathogens which means that antibiotic proliferation is chronologically limited within its life expectancy. Coupled with this, if an antibiotic is highly effective, the scientific and medical community often rally against its usage so that such a tool can be saved in reserve for a global bacterial pandemic. In either scenario, return upon investment is less than what it would be with a different class of medication (e.g. selective serotonin re-uptake inhibitor, statin, hypnotic etc.) which is why pharmaceutical organizations are less interested in research and development dedicated to antibiotic medicine in favor of other, more profitable medication categories. This lack of investment however is myopic and will inevitably backfire upon the pharmaceutical industry as a whole if new antibiotics are not developed because medications used to treat cancer will become less in demand due to the fact that cancer patients are highly likely to acquire an infection during treatment when their immune system is comprised, with this infection often killing the patient if antibiotic solutions are not available. This would expectedly lead to a sharp decline in cancer medication treatment and subsequently pharmaceutical sales of related medications as patients would be likely to adopt living the rest of their life as fully as possible and forgoing treatment as they would be damned if they accept the cancer treatment and develop an infection which kills them but also damned if they don’t accept the treatment and let the cancer run its course which is almost always fatal

To provide comparison of the research, development, and manufacturing contrast between oncology medications and antibiotics, as of 2020, there are currently 800 medications in development for cancer and hypertension whilst only 28 antibiotic medications undergoing that same research phase and development process, with 2 of these antibiotics expected to become fully developed and able to reach the market and patients. The last new antibiotic class, lipopeptides, were introduced in 1984 with a gap referred to as an “antibiotic void” occurring during the 1990’s, 2000’s, 2010’s, and now moving into the 2020’s. The urgency of this threat is projected to become dire within the coming decades, with scientists predicting that by 2050, medicine could potentially come full circle to the pre-antibiotic era, with microbes which are completely and totally resistant to every antibiotic known to medicine

The Evolutionary Reason Human Beings Seek Violence and Conflict

Whilst observing chimpanzees in the wild, Jane Goodall noticed her observed chimpanzee community beginning to divide amongst itself, with some members choosing to spend more time in the northern region of the jungle and others in the south. By separating themselves, these chimpanzees inherently relinquished their right to be recognized as part of their previous clan. This once seemingly peaceful community began to become heavily engaged within primitive warfare and conflict, with the entire community which had moved south annihilated into oblivion by their northern counterparts. Goodall stated upon record that it took her considerable time to reconcile this brutality, as she had always thought of chimpanzees akin to human beings however better, kinder, and gentler. Goodall believed that conflict was a human invention, but eventually realized and accepted that the dark and cruel side of human nature was deeply embedded within the human genome and inherited from primate ancestors. It is most probable that a propensity for brutality, violence, and conflict has been hard coded into human beings genetically, at the fundamental level of deoxyribonucleic acid which create proteins, which produce neurons, and subsequently unique neural traits, such as a propensity for violence behavior(s). It would be advantageous for evolution to have evolved such traits because if a person (or animal) is being attacked, the ability to fight back with deadly force is expediently beneficial. This is believed by most scientists to be the reason why such traits have evolved within human beings. It should be noted, prior to Goodall’s work, scientists had no knowledge of chimpanzees engaging in warfare and/or hunting practices, which makes her work groundbreaking and revolutionary to say the least as it provides unique introspective into human behavior(s)

The Future of Body Modification

Near field communication, often abbreviated as “NFC” is the ability for wireless devices to communicate with eachother and has now made its way into the bodies of human beings with some opting to implant small subdermal microchips using a large gauge hypodermic syringe (e.g. 14 – 18 gauge) which is preloaded so that these individuals gain the ability to start their vehicle(s), open their home door locks, send contact information to another persons smartphone etc., wirelessly and without any intervention or effort upon the end user. This adaptation is referred to as “transhuman” as it goes beyond what the biological human body can do by introducing technology which cannot be evolved into existence. Devices have been developed for a number of different purposes (e.g. vibrating when pointed towards magnetic north turning the body into a compass or implanting a small chip containing tritium gas which glows beneath the skin but is radioactive and therefore not battery powered lasting indefinitely as tritium gas has a 12 year half-life etc.). In 2018, at the University of Colorado, Dr. Carson Bruns and his team developed a technology which allows for smart tattooing in that newly and highly specialized tattoo inks will be able to deliver new functions to the artistic medium of tattooing. The first design invented was a tattoo ink which is sensitive to ultraviolet light which allows it to lay invisible under typical lighting conditions and only appear as a blue hue once outside in the presense of sunlight or an artificial ultraviolet light source. This technology would be practical as well as esthetic as it would allow a person to know when they’ve had too much sun exposure while outside. Bruns’ team has also developed tattoo ink which changes color as the temperature of the body changes which again would be functional as well as artistic, acting as a thermometer to indicate when a person has had too much or too little exposure to cold or heat. Nanotechnology is used to engineer and design tattoo particles which have specialized properties and characteristics (e.g. thermal battery and/or storage mechanism). Real world applications could be spurred by this advent like the ability to keep the entire body at a comfortable temperature at all times, regardless of the environment, if the entire body was tattooed, either visibly with color or invisibly with translucent ink. Specially engineered tattooing can also have medical applications such as that of the distribution of a pharmacological medication or hormone which helps regulate biochemistry (e.g. insulin or neural catecholamines to control mood etc.). World militaries may find use with specially engineered tattoos as well, allowing skin to become more resilient to abrasions or epidermal damage. Specialized tattoo pigments are also tactile sensitive in that when touched, they have the ability to turn on or off as well as perform other functions (e.g. manipulate an options menu upon a screen or act as a controller for a game or software etc.). In 2018, billionaire futuristic Elon Musk unveiled Neuralink, a technology which he states provides the ability of “self-directed evolution”. Neuralink will be installed within the human body by using a specialized, robotic hypodermic syringe to inject an ultra thin mesh, referred to as “neuro lace”, into the neurocortex of the brain, to form a body of electrodes which are able to monitor and influence brain function. These microelectrodes will be able read and write onto neurons; a bi-directional information exchange. This will allow for the downloading and uploading of information to and from the internet, wirelessly. This technology will allow for thoughts to be sent between users in the same format that data is shared online during the modern day using peer to peer networking. This technology will also allow for the control of devices, remotely; in principle, telekinesis. Nanotechnology now provides scientists with the technology required to manufacture electronics small enough to become tattooed, which means that in the future, Neuralink will only require a small, cranial tattoo instead of a cranial implant

The Causation and Cure for Colorblindness

Being colorblind is more difficult than most people believe as those affected often cannot match clothing colors, tell when fruit is ripe, tell when meat is cooked, or tell when traffic lights are various colors in certain lighting conditions (e.g. flashing red being mistaken for flashing yellow). Color vision is trichromatic with 3 types of cone cells within the eyes which consist of blue, green, and red, which are sensitive to short, medium, and long wavelengths of light, with each cone permitting an observer to view approximately 100 different shades. When all shades are combined, the human eye can observe approximately 1,000,000 (1 million) different colors. Colorblindness can stem from faulty cone cells or an interruption between the pathway of the cones and the brain. Colorblindness has caused vehicular deaths due to accidents around the world which have occurred most often because a driver perceived a light as yellow when it was red in reality. Neuroscientist Professor Jay Neitz (pronounced “nites”), a color researcher at the University of Washington in the U.S. and his spouse, geneticist Maureen Neitz, have teamed up to try and cure colorblindness. Gene therapy is currently being researched around the world and scientists believe that colorblindness will be cured using gene therapy in the near future. Male squirrel monkeys are naturally red-green colorblind and gene studies have demonstrated that these monkeys can be afforded color vision after having a gene delivered into the cone cells within the eye. The gene produced transforms a subset of the green cones within the male squirrel monkeys eyes to force them to become red cones, red cones which have hijacked the squirrel monkeys neural circuitry which was previously utilized solely for blue-yellow color vision, essentially bifurcating into red-green cones and blue-yellow cones so that the monkeys examined developed full color vision like human beings as of 2019. The Neitz’s confirmed this by providing male squirrel monkeys colorblind examinations which when answered correctly, delivered a small treat of food after having undergone gene therapy. Trials in human beings have yet to start as the Neitz’s believe that this step is still a few years away, but expected to initiate during the 2020’s

A Revolutionary Breakthrough in Oncology Treatment

Cancer kills 9,000,000 (9 million) people each year and despite having searched for centuries, a cure has yet to be discovered by scientists. At the center of the immune system is the T cell, a type of leukocyte which respond against bacterial and viral infections alike in an effort to keep their host healthy and alive. T cells determine between threatening and non-threatening foreign and non-foreign bodies within a host by leveraging a molecule upon the surface of all cells referred to as the “T cell receptor”. Jim Allison was the first person to successfully isolate and purify the molecule which recognizes this lock and key model for infectious disease, auto-immune disease, and other innocuous substances within the body be they foreign or internally created. In 1987, French scientist Pierre Golstein and his team discovered a new protein upon the surface of T cells which he named “CTLA-4”. To study CTLA-4 in laboratory rats, Allison had to build and design a rat antibody, a Y shaped protein which would trigger a reaction by CTLA-4. Cancers are mutations and should in theory be visible to the immune system, which is why the scientific community has struggled with the paradox of why tumors go undetected by the immune system for decades. There is no discernible reason as to why the immune system can recognize and resist influenza or any other foreign or domestic body but not cancer. Allison theorized that tumors have evolved an ability to fool the immune system, engaging CTLA-4 which turns on the T cells response to halt its search and destroy measures. Allison hypothesized that if he inserted a Y shaped antibody to block the gap in between the tumor and T cells, the tumor would no longer have its ability to hide, a trait which has been evolved by tumor cells over hundreds of millions of years. This would allow the T cell to infiltrate, attack from within the tumor, shrink, and ultimately kill the growth. Allison spent the next decade trying to turn this revolutionary breakthrough discovery into a medication which could be provided to cancer patients. Allison found Alan Korman, a scientist creating medications for auto-immune disease which provided him with the expert he required to turn this idea into a reality. Korman was tasked with taking the CTLA-4 antibody which Allison and partner Max Krummell developed for laboratory rats, and turn it into a medication which could safely work within human beings with this medication subsequently being named “Ipilimumab” (pronounced “ipi-lim-ooh-mab”). Korman ended up collaborating with a friend from graduate school, Nils Lonberg to accomplish this task. Ipilimumab consists of an intramuscular injection into the leg and a 90 minute intravenous medication drip in comparison to chemotherapy and radiation therapy which take months of treatment to complete and have devastating effects upon overall health as both bad and good tissue are destroyed in an effort to eradicate all tumor cells. Allison’s work with laboratory rats demonstrated that with the help of this newly developed antibody, T cells gained the ability enter into tumors and expand their size in an effort to destroy them from the inside out. This means that the fact that tumors grow initially upon administration is a positive marker and indicative of the medication working as it demonstrates successful infiltration of the tumor cells themselves. Patients often report feeling better after a few treatment sessions, sometimes even a single session, despite computer tomography scans demonstrating that their tumors are growing larger, which under normal circumstances would make a patient feel worse. Some patients even noted increased improvement after having stopped the Ipilimumab treatment, with no further therapy required. On March 25, 2011, the U.S. Food and Drug Administration released approval for Ipilimumab. Ipilimumab and its successors have treated nearly 1,000,000 (1 million) patients worldwide with many of these patients achieving permanent remission which is essentially the definition of having been cured of cancer. Although these medications do not work in every single case, they have definitively demonstrated to be a miracle medication for hundreds of thousands of people thus far. After completing this revolutionary discovery, Allison was awarded the Nobel Prize in Medicine in 2018 for his series of discoveries related to T cells and their ability to halt cancer in its progression in perpetuity