Methamphetamine causes a rush of dopamine to be released which provides euphoria with a rapid onset. Typically the brain has a dopamine level of 50 – 75 units, but when methamphetamine is present within the system, this value bounds to become 900 – 1250 units, larger than any other drug. Over time, methamphetamine destroys the brain’s ability to produce dopamine naturally, allowing levels to fall below baseline, causing a person who uses the substance to crave more and more to feel normal and balanced. To provide a scale of reference, cocaine typically produces dopamine levels of 100 – 350 units
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