Tag: patient

The Argument Against Private Corporation Umbilical Cord Blood Storage

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Canadian Blood and Tissue Bank Insception Life Blood claims that 80 life threatening diseases (e.g. various cancers, metabolic diseases, immune diseases etc.) can be treated with umbilical cord blood, and that these diseases have been treated with success for over 2 decades, with over 45,000 pediatric transfusions worldwide. The majority of these transfusions however were accomplished due to public cord blood banks. Physicians can tap into worldwide public registries with nearly 1,000,000 (1 million) donors to find a match for a patient and this service is free. In the setting of leukemia or a genetic defect, physicians would want to use cord blood which is not biologically related to the patient to avoid having the problem continue. The American Academy of Pediatrics states, “private storage of cord blood as biological insurance should be discouraged”. There is a caveat to this however, in the case of a child having a genetic defect, it is recommended that the family save the cord blood of the next child, if another child is born. It is believed that private cord blood corporations leverage fear, uncertainty, and timed pressure to cajole families into deciding to privately store cord blood. Insception Life Blood has stored cord blood from 70,000 infants yet only 14 were released for transplant, a value of 1 in 5000

The 3 Conditions Required to Diagnose a Patient as Brain Dead

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3 conditions are necessary for a patient to reach prior to being categorized as brain dead which include being within a persistent comatose state which does not respond to pain stimuli (e.g. nail bed pressure, sternal rub, pressure upon the orbital rim of the face etc.), possessing absent brain stem reflexes (e.g. pupillary light reflex, oculocephalic reflex, coughing gag reflex etc.), and possessing a lack of spontaneous respiration, if a patient is unable to breathe upon their own accord. If a patient possesses all 3 of these metrics, they are considered brain dead and legally deceased within the U.S.. If tests are inconclusive, ancillary examinations can be provided to determine definitively whether or not a person is brain dead (e.g. electroencephalograph, transcranial doppler ultrasound, diagnostic cerebral angiogram etc.) as well as other tests which can be performed

Gender Reassignment Surgery: Male to Female

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The reason gender reassignment surgery is possible is because all human beings begin life with the same anatomy, with the ovaries starting from the gonadal ridge, becoming testicles if they drop and remaining as ovaries if they do not. In addition to this, the clitoris is effectively a short penis as both genitalia are physically and anatomically identical (e.g. nerve ending bundles, interior connection and placement, sexual function etc.). When male anatomy is transitioned into female anatomy, a reversal of embryology occurs. When a biological male transitions to become female, during surgery, the scrotal skin is excised after which it is opened to form the labia majora and labia minora, and part of it is utilized to line the new vaginal cavity. The testicles are removed in their entirety and the cliterous is formed using the head of the penis which allows the cliterous to function as it does upon the body of a biological female, with most patients able to orgasm post surgery once healed. The volume of erectile tissue is decreased as the penis is effectively folded over, but because the nerves and arteries remain attached, sensation remains. Once the cliterous is sutured into place, the vaginal tunnel is created which is the most difficult aspect of the entire surgical procedure. A space is created between the bladder and the rectum which is difficult as both structures contain significant blood supply and injury to these systems can cause major complications. A skin graft from the scrotum is then set in place onto a cylindrical mold and sutured around it once the cavity is produced so that it can be implanted. Hair follicles are obliterated as they will continue to grow internally if not removed which would cause further complications. The mold used is an approximation of the average male penis which allows surgeons to create a cavity large enough to allow for sexual intercourse if desired. Small cosmetic details are taken care of after which the patient is sutured and migrated out of the operating theater so that they can be left to rest and reawaken after the anesthesia administered wears off

The Argument Against Stem Cell Research and Why This Will No Longer be a Problem in the Future

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The reason stem cell research is controversial for some is because it is viewed as damaging and harvesting from one life to help another. This argument may be obsolete in the future as scientists are now discovering ways to create stem cells from cells within the body (e.g. skin cells etc.). The traditional method to create a stem cell was to take a skin cell, remove the deoxyribonucleic acid from its nucleus, placing it into an egg which does not have deoxyribonucleic acid but is capable of changing deoxyribonucleic acid, turning it into a stem cell which has the patients genome ascribed unto it. The new method involves placing 4 genes into the nucleus of the skin cell and allowing time to pass, as the genes reorganize the deoxyribonucleic acid so that it begins to appear as stem cell deoxyribonucleic acid, which changes the skin cell and causes it to shrink, losing its outside, converting it into an embryonic stem cell with the only difference between this method and traditional embryonic stem cell creation method being that this technique contains the deoxyribonucleic acid of the patient it is being inserted into. The 4 genes inserted into the cell create 4 proteins which exist naturally within an egg. These proteins trigger the skin cell deoxyribonucleic acid to arrange itself identically to how it would within an embryonic stem cell. Scientists refer to this type of cell as “induced pluripotent stem cells”, commonly abbreviated as “IPS cells”. Ideally, scientists want induced pluripotent stem cells to function identically to natural embryonic stem cells, avoiding the creation of unwanted cells which can lead to cancer. Researchers have discovered that some laboratory created stem cells fail to carry out the task provided and worse yet, some cause cancer to develop. Scientists are currently pursuing 2 paths to alleviate this problem, the first being the attempt to develop induced pluripotent stem cells which function identically to natural embryonic stem cells and the second being to create a system to recognize which induced pluripotent stem cells will fail in an effort to exclude these cells from being inserted into the human body

The Test Subject and Scientific Experiment Which Proved the Fear Response in Human Beings Does Not Solely Reside Within the Amygdala

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Justin Feinstein is one of the few scientists who have been able to study a woman who has zero fear response. To protect the woman’s identity, this subject is known only as “S.M.”, and Feinstein has had the opportunity to work with her under laboratory conditions and in real world scenarios (e.g. coffee meeting, sporting event, professional conference etc.) for the past 15 years as of 2018. S.M.’s lack of fear has had unexpected consequences within her life, as she displays no sense of typical fear induced scenarios (e.g. personal space, feeling completely comfortable being nose to nose with a complete stranger as the concept of personal space and discomfort has no meaning), heightened by the fact that S.M. does not produce typical signals of distrust when interacting with a novel person. S.M. lacks fear because she is without her amygdala, a physical trait observed in very few human beings, making S.M. one of the only people in the world to produce this physiology. S.M. has no amygdala because she has been diagnosed with Urbach-Wiethe Disease (pronounced “urr-bock vee-they”). The underlying etymology of Urbach-Wiethe Disease is still unknown but in patients with the condition, specific portions of the brain, in both hemispheres, can become subject to selective calcification which erodes the ability to function as designed. The amygdala acts as a sentry for potential fearful stimuli, and produces a response accordingly. The removal of or inability of the amygdala to work correctly results in a complete and total lack and/or loss of fear. This condition has caused S.M. considerable difficulty during her life as she has experienced dangerous interactions with those participating within the illicit drug trade. Upon one occasion, a stranger ran up to S.M., placed a firearm against her temple, and yelled “bang!”. Neighbors witnessed this event and notified law enforcement which puzzled S.M. as she did not view the event as dangerous or alarming and therefore did not expect to be contacted by the police. When the human body detects the intake of too much carbon dioxide, it can become pushed into a state of alarm. Feinstein wanted to better understand what would occur if he interfered with S.M.’s respiratory system, using 35% carbon dioxide during the first trial run. Feinstein found that S.M. was immediately fearful after a single intake breath, despite his original hypothesis of no fear response being observed. S.M. displayed an immediate and dramatic fear response with S.M. herself describing it as the “most intense fear ever felt” during her entire life. This single breath was revolutionary for neurology as it definitively proved that the amygdala is not the only region of the brain which controls and is related to fear

The Rationale Why Pharmaceutical Organizations are Not Incentivized to Develop Antibiotics and Why This is Dangerous for the Worlds Next Pandemic

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Within 5 short years of release, approximatly 20% of antibiotics become subject to resistance from bacterial pathogens which means that antibiotic proliferation is chronologically limited within its life expectancy. Coupled with this, if an antibiotic is highly effective, the scientific and medical community often rally against its usage so that such a tool can be saved in reserve for a global bacterial pandemic. In either scenario, return upon investment is less than what it would be with a different class of medication (e.g. selective serotonin re-uptake inhibitor, statin, hypnotic etc.) which is why pharmaceutical organizations are less interested in research and development dedicated to antibiotic medicine in favor of other, more profitable medication categories. This lack of investment however is myopic and will inevitably backfire upon the pharmaceutical industry as a whole if new antibiotics are not developed because medications used to treat cancer will become less in demand due to the fact that cancer patients are highly likely to acquire an infection during treatment when their immune system is comprised, with this infection often killing the patient if antibiotic solutions are not available. This would expectedly lead to a sharp decline in cancer medication treatment and subsequently pharmaceutical sales of related medications as patients would be likely to adopt living the rest of their life as fully as possible and forgoing treatment as they would be damned if they accept the cancer treatment and develop an infection which kills them but also damned if they don’t accept the treatment and let the cancer run its course which is almost always fatal. To provide comparison of the research, development, and manufacturing contrast between oncology medications and antibiotics, as of 2020, there are currently 800 medications in development for cancer and hypertension whilst only 28 antibiotic medications undergoing that same research phase and development process, with 2 of these antibiotics expected to become fully developed and able to reach the market and patients. The last new antibiotic class, lipopeptides, were introduced in 1984 with a gap referred to as an “antibiotic void” occurring during the 1990’s, 2000’s, 2010’s, and now moving into the 2020’s. The urgency of this threat is projected to become dire within the coming decades, with scientists predicting that by 2050, medicine could potentially come full circle to the pre-antibiotic era, with microbes which are completely and totally resistant to every antibiotic known to medicine

A Revolutionary Breakthrough in Oncology Treatment

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Cancer kills 9,000,000 (9 million) people each year and despite having searched for centuries, a cure has yet to be discovered by scientists. At the center of the immune system is the T cell, a type of leukocyte which respond against bacterial and viral infections alike in an effort to keep their host healthy and alive. T cells determine between threatening and non-threatening foreign and non-foreign bodies within a host by leveraging a molecule upon the surface of all cells referred to as the “T cell receptor”. Jim Allison was the first person to successfully isolate and purify the molecule which recognizes this lock and key model for infectious disease, auto-immune disease, and other innocuous substances within the body be they foreign or internally created. In 1987, French scientist Pierre Golstein and his team discovered a new protein upon the surface of T cells which he named “CTLA-4”. To study CTLA-4 in laboratory rats, Allison had to build and design a rat antibody, a Y shaped protein which would trigger a reaction by CTLA-4. Cancers are mutations and should in theory be visible to the immune system, which is why the scientific community has struggled with the paradox of why tumors go undetected by the immune system for decades. There is no discernible reason as to why the immune system can recognize and resist influenza or any other foreign or domestic body but not cancer. Allison theorized that tumors have evolved an ability to fool the immune system, engaging CTLA-4 which turns on the T cells response to halt its search and destroy measures. Allison hypothesized that if he inserted a Y shaped antibody to block the gap in between the tumor and T cells, the tumor would no longer have its ability to hide, a trait which has been evolved by tumor cells over hundreds of millions of years. This would allow the T cell to infiltrate, attack from within the tumor, shrink, and ultimately kill the growth. Allison spent the next decade trying to turn this revolutionary breakthrough discovery into a medication which could be provided to cancer patients. Allison found Alan Korman, a scientist creating medications for auto-immune disease which provided him with the expert he required to turn this idea into a reality. Korman was tasked with taking the CTLA-4 antibody which Allison and partner Max Krummell developed for laboratory rats, and turn it into a medication which could safely work within human beings with this medication subsequently being named “Ipilimumab” (pronounced “ipi-lim-ooh-mab”). Korman ended up collaborating with a friend from graduate school, Nils Lonberg to accomplish this task. Ipilimumab consists of an intramuscular injection into the leg and a 90 minute intravenous medication drip in comparison to chemotherapy and radiation therapy which take months of treatment to complete and have devastating effects upon overall health as both bad and good tissue are destroyed in an effort to eradicate all tumor cells. Allison’s work with laboratory rats demonstrated that with the help of this newly developed antibody, T cells gained the ability enter into tumors and expand their size in an effort to destroy them from the inside out. This means that the fact that tumors grow initially upon administration is a positive marker and indicative of the medication working as it demonstrates successful infiltration of the tumor cells themselves. Patients often report feeling better after a few treatment sessions, sometimes even a single session, despite computer tomography scans demonstrating that their tumors are growing larger, which under normal circumstances would make a patient feel worse. Some patients even noted increased improvement after having stopped the Ipilimumab treatment, with no further therapy required. On March 25, 2011, the U.S. Food and Drug Administration released approval for Ipilimumab. Ipilimumab and its successors have treated nearly 1,000,000 (1 million) patients worldwide with many of these patients achieving permanent remission which is essentially the definition of having been cured of cancer. Although these medications do not work in every single case, they have definitively demonstrated to be a miracle medication for hundreds of thousands of people thus far. After completing this revolutionary discovery, Allison was awarded the Nobel Prize in Medicine in 2018 for his series of discoveries related to T cells and their ability to halt cancer in its progression in perpetuity

The Development of Modern Institutionalized Psychological Torture as a Means of Interrogation

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In the 1950’s, Scottish psychiatrist Ewen Cameron started experimenting upon his own patients which ushered in the modern age of the psychological techniques leveraged by governments to extract information from high value targets and low level targets alike. In 1951, the U.S., the U.K., and Canada began developing the Survival Evasion Resistance Escape program, abbreviated as “SERE” (pronounced “sear”) designed for when domestic soldiers became captured by enemy forces (e.g. aircraft shot down over enemy lines) as well as techniques which could be used against captured Soviets. This research became dominant within Canadian universities for almost a decade, with researchers beginning similar psychiatric experiments within psychiatric hospitals in the U.K. In the U.S. The U.S. Central Intelligence Agency dominated most research and had over 160 secret projects within 80 institutions, comprising a total of $25,000,000 ($25 million) allocated for human experimentation. This project was code named “MK Ultra”. In 1963, many of Cameron’s psychological experiments were codified for the first time and compiled within the Kubark Counterintelligence Interrogation hand guide, a book which is now declassified and freely available online. The term “kubark” is a cryptonym, the name for the Central Intelligence Agency itself. This content became the foundation for the method of psychological interrogation and psychological torture which the Central Intelligence Agency disseminated across the U.S. intelligence community and worldwide among allies for 30 years after its initial release. Since the 1950’s, confirmed cases backed by evidence and testimony of these techniques of torture being used have been recognized or admitted to by governments in 28 nation states including Afghanistan, Argentina, Australia, Borneo, Brazil, British Guyana, British Cameroon, Canada, Chile, Cuba, the UK, Guatemala, Honduras, Iran, Iraq, Israel, Lithuania, Morocco, Northern Ireland, Pakistan, the Philippines, Poland, Romania, Thailand, Turkey, Uruguay, Vienna, and Yemen

Whilst I rarely if ever will submit an opinion upon this blog, I feel that it is important to state that the Kubark Counterintelligence Interrogation hand guide is now declassified and been made public. To educate yourself so that these techniques cannot be used against you, click here to read the Kubark Counterintelligence Interrogation hand guide

The Reason Weight Loss is Required Prior to Bariatric Surgery

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The reason bariatric patients are required to lose weight before undergoing bariatric surgery is because the liver becomes enlarged in obese patients and this enlarged liver sits directly atop of the area which needs to be operated upon. Shrinking of the liver is crucial prior to surgery to ensure the surgery is performed as safely as possible